SYNTHESIS OF TRIGONELLINE AND NICOTINAMIDE LINKED PRODRUGS OF 5-AMINOSALICYLIC ACID (5-ASA) WITH ANALGESIC AND ANTI-INFLAMMATORY EFFECTS
نویسندگان
چکیده
منابع مشابه
Role of 5-aminosalicylic acid (5-ASA) in treatment of inflammatory bowel disease: a systematic review.
Authors' objectives To perform a systematic review of the efficacy of 5-aminosalicylic acid (5-ASA) compounds (oral and topical) in the treatment of inflammatory bowel disease (IBD), both ulcerative colitis (UC) and Crohn's disease (CD), in the acute phase for inducing remission and for the prevention of relapses or recurrences. Also, to evaluate the influence of several factors (such as dosage...
متن کاملPharmacokinetics in Wistar Rats of 5-[(4-Carboxybutanoyl)Amino]-2-Hydroxybenzoic Acid: A Novel Synthetic Derivative of 5-Aminosalicylic Acid (5-ASA) with Possible Anti-Inflammatory Activity
5-[(4-carboxybutanoyl)amino]-2-hydroxybenzoic acid (C2) is a novel synthetic derivative of 5-aminosalicylic acid (5-ASA), which is currently being evaluated ex vivo as an anti-inflammatory agent and has shown satisfactory results. This study aimed to obtain the pharmacokinetic profiles, tissue distribution and plasma protein binding of C2 in Wistar Rats. Additionally, an HPLC method was develop...
متن کاملElectrochemical Synthesis of 5-Aminosalicylic Acid from 5- Nitrosalicylic Acid in Alkaline Media
5-Aminosalicylic acid (5-ASA) is currently prepared by electrochemical reduction of 5-nitrosalicylic acid (5-NSA) in acidic media. In this work, electrolytic reduction of 5-NSA in alkaline media is presented. Reactionconditions and parameters such as anode and cathode electrodes, electrolyte type, reaction time, temperature,current, and the pH for isolation of product are investigated. The yiel...
متن کاملSynthesis and evaluation of a prodrug of 5-aminosalicylic acid for the treatment of ulcerative colitis
Objective(s): This study is aimed to design and synthesize a prodrug of 5-aminosalicylic acid and evaluate its ameliorative effect on experimental ulcerative colitis (UC).Materials and Methods: 5-Aminosalicylic acid-alanine (5-ASA-ALA) was synthesized and characterized. Its stability study was conducted in rat plasma and in the gastroint...
متن کاملPENTASA Tablets and Sachets NAME OF THE MEDICINE Mesalazine (5-ASA) Synonyms: 5-aminosalicylic acid 5-amino 2-hydroxybenzoic acid
PHARMACOLOGY Pharmacotherapeutic group: Intestinal anti-inflammatory agents (A07 EC02). Actions: It has been established that mesalazine is the active component of sulfasalazine, which is used for the treatment of ulcerative colitis and Crohn’s disease. Based on clinical results, the therapeutic value of mesalazine after oral as well as rectal administration appears to be due to a local effect ...
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ژورنال
عنوان ژورنال: Bulletin of Pharmaceutical Sciences. Assiut
سال: 2005
ISSN: 1110-0052
DOI: 10.21608/bfsa.2005.65398